| SACO | Bristol |  |
| Saint-Gobain Performance Plastics Rencol Ltd | Bristol | |
| Samson Office Supplies Limited | Somerset | |
| Seasalt | Cornwall | |
| Sector Marketing | North Somerset | |
| Seepex UK Limited | Somerset | |
| Severn Controls Limited | Gloucestershire | |
| Sharps Brewery | Cornwall | |
| Siemens VAI Metals Technologies Ltd | Dorset | |
| Somar | Cornwall | |
| Space Catering Equipment | Gloucestershire | |
| Space Engineering Services Ltd | Bristol | |
| Spiral Construction Ltd | Cornwall | |
| Spirent Communications (SW) Ltd | Devon | |
| St Austell Brewery Company Ltd | Cornwall | |
| St Austell Printing Company Ltd | Cornwall | |
| Stirling Dynamics Limited | Bristol | |
| Stubbs Rich LLP | North Somerset | |
| Sustain Ltd | Bristol | |
| Swallowfield | Somerset | |
| Syntech Technologies | Devon | |
| Tamar Foods | Cornwall | |
| TasteTech | Bristol | |
| TDSi Ltd | Dorset | |
| Tecan Limited | Dorset | |
| Tetra Pak CPS Ltd | Dorset | |
| The ai Corporation | Devon | |
| The Book Depository Ltd. | Gloucestershire | |
| The Chord Company Ltd | Wiltshire | |
| The Consortium | Wiltshire | |
| The Crescent Specialist Dental Centre | Devon | |
| The Dartington Hall Trust | Devon | |
| The Hotel & Extreme Academy | Cornwall | |
| The Plastic Surgeon | Devon | |
| The Premiere Kitchen Company | Gloucestershire | |
| The Roman Group | Dorset | |
| The Seafood Restaurant | Cornwall | |
| The Tracklement Company Ltd | Wiltshire | |
| The Venus Company Ltd | Devon | |
| The Waveguide Solution Limited | Devon | |
| Thrings | Wiltshire | |
| Tileflair Limited | Bristol | |
| TJ International Limited | Cornwall | |
| TLH Leisure Resort | Devon | |
| Total Disc Repair | Dorset | |
| Total Ltd | Gloucestershire | |
| Trackwise Designs Ltd | Gloucestershire | |
| Trinity Protections Systems Ltd | Devon | |
| Triodos Bank | Bristol | |
| Tungum Limited | Gloucestershire | |
| Twofour Digital Ltd | Devon | |
| UCAS | Gloucestershire | |
| Ultra Electronics BCF | Gloucestershire | |
| Valeport Limited | Devon | |
| Viper Subsea Ltd | Bristol | |
| Vortok International Limited | Devon | |
